Endocrine Abstracts

Introduction: Collision tumors of the thyroid are neoplasms of distinct histology located within the same gland. Although rare, the most commonly described collision tumors of thyroid origin are medullary and papillary carcinomas. We describe a case of co-existence of a benign follicular adenoma in a dominant nodule with a micropapillary and a micromedullary carcinoma in a patient carrying a heterozygous germline RET polymorphism.Case report: A 74-year-o...

Introduction: rhPTH(1-84) replacement is the treatment of choice in adults with hypoparathyroidism not adequately controlled on standard therapy. Although increased bone turnover markers have consistently been reported in trials of safety and efficacy, marked elevations coupled with significant symptoms have been rare. We describe a case of increased treatment-induced bone turnover, necessitating significant therapeutic adjustments and monitoring.Case re...

Aim: Infertility, defined as the non-achievement of pregnancy by a couple after 12 months of free sexual intercourse, affects 4 - 17% of couples worlwide. In 20% of cases, the cause is found exclusively or mainly in the man. The purpose of this study is to evaluate infertility as a risk factor for increased psychological stress.Material and Methods: A case – control study was conducted in which the levels of psychological stress of men with infertil...

Introduction: The maximum period of bisphosphonate use has not been determined, as their long-term appliance has been associated with adverse effects, such as osteonecrosis of the jaw (ONJ) and atypical femoral fractures (AFF).The aim of this study was to systematically present existent data regarding the effect of bisphosphonate discontinuation on fracture risk and bone mineral density (BMD).Methods/design: MEDLINE, Scopus, EMBASE...

Introduction: Asplenia has been reported in 10% of patients with type 1 APS (APS-1), but has never been reported in APS-2. We describe a patient with presumed APS-2 and aplenia.Case report: A 69-year-old woman was diagnosed with B12 deficiency with severe anemia at age 21 and insulin dependent diabetes mellitus at age 33, following routine testing. At 59, she was hospitalized with salt wasting and a diagnosis of Addison’s disease was made, which was...

Background: Carney complex (CNC) is a rare multiple neoplasia syndrome, its commonest endocrine manifestation being ACTH-independent Cushing’s syndrome, histologically characterized by primary pigmented nodular adrenocortical disease (PPNAD). There is significant genetic and phenotypic heterogeneity, but deletions at 17q24.2 are rare. We describe the particular characteristics of a patient with a microdeletion in this area.Case report: A 37-year-old...

Background: Androgen co-secretion in patients with adrenal Cushing’s syndrome is considered a marker of malignancy. Mixed secretion by benign adrenocortical tumors is rare. We describe a case of a middle aged woman presenting with Cushing’s syndrome and polycythemia.Case report: A 57-year-old lady was referred by the Hematology Service to our Endocrine Clinic for evaluation of an adrenal mass found in an abdominal CT in the course of investigat...

Introduction: Collision thyroid tumors are defined as independent and histologically distinct tumors that coexist within the thyroid gland. Collision thyroid tumors are rare and their prevalence is unknown.Methods: A retrospective, registry-based study was performed by reviewing the electronic medical records of the Department of Endocrinology, Ippokratio General Hospital of Thessaloniki, Greece. All patients with thyroidectomy and thyroid cancer diagnos...

According to recent research in the field of Psychoneuroendocrinology each stressor appears to have its own neurochemical signature. The present study examined whether keeping a secret stimulates the HPA or the SAM axis as well as cortisol involvement in lying.Methods: Sixty seven (N=67) healthy young male medical students participated in the study. Students were randomly assigned in 3 groups. All students were informed that they were about to have a 5 m...

Objective: Thyroid autoimmunity has been proposed as a risk factor for impaired health-related Quality of Life (HRQoL), depression and anxiety, though evidence is still limited. The aim of the current study is to assess the association of thyroid autoimmunity with quality of life in patients with benign thyroid disease.Design: A cross-sectional study was implemented, that included consecutive patients with benign thyroid diseases who visited the outpatie...